A recent study indicates that individuals who stop using blockbuster weight-loss injections like semaglutide or tirzepatide can put back on lost weight at a significantly accelerated pace than those who stop traditional lifestyle regimens.
Findings released in a major medical journal points out that while overweight people can lose a large proportion of their body weight while using the jabs, the mass is regained at an estimated rate of 0.8 kg per month upon discontinuation.
"People buying these treatments should be cognizant of the danger of fast weight regain when the therapy ends," cautioned researcher Dr. Susan Jebb.
That rate of regain implies a return to starting weight in about a year and a half.
Comparing Treatments
The study, which examined dozens of trials involving thousands of participants, compared the effects of GLP-1 agonists with other pills.
Scientists emphasize that people who lose weight through diet and exercise generally have a slower weight regain—perhaps 100 grams monthly—after stopping.
Explaining the Quick Rebound
Doctors propose the mode of action of the jabs is key to understanding the accelerated rebound.
GLP-1 drugs mimic a body's own chemical called GLP-1, which controls appetite.
"Artificially providing GLP-1 levels several times higher than the body's typical production might result in the system to generate a reduced amount of its endogenous hormone, and could lessen responsiveness to its actions," explained Dr. Adam Collins, a dietetics expert.
"Discontinuation of this medication results in hunger is unsuppressed, making excessive eating far more likely."
A Chronic Condition?
Medical guidelines advise the jabs for individuals with weight-linked medical conditions, accompanied by prescribed diet and exercise modifications.
Many experts argue that, given the significant potential of weight regain, the therapy should be considered ongoing.
This view is supported by drug manufacturers, who state that the results "highlight the long-term character of obesity," akin to managing diseases like diabetes.
Patient Testimonies
Users who have come off the jabs explain a sudden resurgence of cravings.
"It felt as if a switch that goes on and I was suddenly extremely hungry," said a patient.
This challenge is compounded if patients have not adopted sustainable lifestyle or habit modifications during treatment.
Growing Adoption
Figures indicate that millions of adults in the UK have used weight-loss jabs in the last 12 months, with desire remaining high.
- Use is higher among women compared to men.
- The 40s and 50s demographic shows the greatest usage rates.
- Many obtain the medications through private healthcare rather than the NHS.
In conclusion, experts emphasize that while the jabs are effective tools for shedding pounds, they are not a standalone cure and long-term success relies on integrated lifestyle support.
